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目的探讨p73基因启动子区甲基化与乳头状甲状腺癌的关系。方法收集109例乳头状甲状腺癌组织及癌旁组织,检测p73基因启动子区甲基化及mRNA表达水平,分析p73基因甲基化水平与患者临床病理特征的关系。结果甲状腺癌组织p73基因甲基化率高于癌旁组织(89.91%vs.11.93%)(P<0.01),而p73 mRNA阳性表达率低于癌旁组织(15.60%vs.100%)(P<0.01)。p73基因甲基化与甲状腺癌患者的年龄、性别、临床分期无明显相关性(P>0.05),但与患者淋巴结转移有关(P<0.05)。结论 p73在乳头状甲状腺癌中低表达,p73基因甲基化水平与甲状腺癌的发生、发展有关。
Objective To investigate the relationship between methylation of p73 gene and papillary thyroid carcinoma. Methods 109 cases of papillary thyroid carcinoma tissues and adjacent tissues were collected. The methylation of p73 gene promoter region and mRNA expression level were detected. The relationship between p73 methylation level and clinicopathological features was analyzed. Results The methylation rate of p73 in thyroid cancer was higher than that in paracancer (89.91% vs.11.93%, P <0.01), while the positive rate of p73 mRNA was lower than that in paracancer (15.60% vs.100%) (P <0.01). The methylation of p73 gene had no significant correlation with the age, sex and clinical stages of thyroid cancer (P> 0.05), but was related to lymph node metastasis (P <0.05). Conclusion The expression of p73 is low in papillary thyroid carcinoma, and the methylation of p73 gene is related to the occurrence and development of thyroid cancer.