葡萄球菌 A蛋白(Staphylococcalprotein A,SPA)是某些金黄色葡萄球菌的胞壁蛋白。十年来,依据SPA能结合人和多种哺乳动物血清IgGFc段的免疫学特性,把它作为免疫吸附剂在体外血浆灌流吸附封闭因子治疗肿瘤已取得一定疗效。近年来发现经体外免疫吸附的血浆能滤取到SPA,促进了人们将SPA直接体内注射治疗肿瘤的研究。本文就 SPA体内注射的代射、毒性作 Staphylococcal protein A (SPA) is a cell wall protein of certain Staphylococcus aureus. In the past decade, SPA has been used as an immunoadsorbent for in vitro plasmapheresis adsorption and blocking factor to treat tumors based on the immunological characteristics of human and various mammalian serum IgG Fc segments. In recent years, it has been found that in vitro immunoadsorption of plasma can be filtered out to SPA, which promotes the study that SPA directly injects and treats tumors in vivo. In this article, on behalf of the SPA in vivo injection, toxicity