作者用~3H-米托蒽醌给大鼠和小鼠作静脉和肌肉注射。按二室模型计算该药在其体内的药代谢动力学参数。结果表明:该药肌肉注射吸收迅速而完全,组织分布广,以肝脏分布最高,其次,依次为肠、肾、肺、心脏、肌肉及脑。该药排泄缓慢,T_(1/2)为42.56小时。在给药72小时内,从尿中排出约为给药量的7％,主要是该药的代谢产物。从粪便中排出为给药量的43％。 The authors used ~ 3H-mitoxantrone to rats and mice for intravenous and intramuscular injection. The two-compartment model was used to calculate the pharmacokinetic parameters of the drug in the body. The results showed that the drug was rapidly and completely absorbed by the muscle, the tissue was widely distributed, the liver was the highest, followed by the intestine, kidney, lung, heart, muscle and brain. The drug excreted slowly, T_ (1/2) was 42.56 hours. Within 72 hours of administration, about a 7% of the dose is excreted from the urine, mainly the metabolites of the drug. Excreted from the feces as the dose of 43%.