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肿瘤坏死因子（ＴＮＦ） 是一种重要的促炎症因子和免疫调节因子。研究发现在活动期炎症性肠病患者粪便和血清中ＴＮＦ 浓度升高， 其主要来源于肠粘膜。ＴＮＦ在炎症性肠病的发病机制中起重要作用， ＴＮＦ抑制剂的应用可能成为治疗炎症性肠病的有效方法
Tumor necrosis factor (TNF) is an important proinflammatory and immunomodulatory factor. The study found that in the active stage of inflammatory bowel disease in patients with excretion and serum TNF levels increased, mainly from the intestinal mucosa. TNF plays an important role in the pathogenesis of inflammatory bowel disease and the use of TNF inhibitors may be an effective method for the treatment of inflammatory bowel disease