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2型糖尿病低血糖发作患者33例,检测身高、体重、BMI、血压、血糖、血脂、尿酸、尿微量蛋白、心电图。对比分析两组患者低血糖发作前及低血糖发生时QT间期、Tp-Te间期,计算QTc及Tp-Te/QT的变化。结果糖尿病组低血糖发生前后QT间期(393.13±41.72ms vs 394.63±35.67ms)、QTc(436.13±30.70ms vs 435.50±46.97ms)无统计学差异;Tp-Te(89.06±16.86ms vs 98.88±23.08ms P=0.0325)、Tp-Te/QT(0.23±0.07 vs 0.25±0.06,P=0.0318)有统计学差异。结论:糖尿病患者低血糖发生时Tp-Te间期及Tp-Te/QT增大,提示糖尿病患者低血糖时心血管事件的增加,可能与低血糖发生时心脏复极化异常相关;
33 patients with hypoglycemic episodes of type 2 diabetes mellitus were enrolled in this study. Height, weight, BMI, blood pressure, blood glucose, blood lipid, uric acid, urine microalbumin and electrocardiogram were detected. The changes of QTc and Tp-Te / QT in QT interval and Tp-Te interval before and during hypoglycemia were compared between the two groups. Results QT interval (393.13 ± 41.72ms vs 394.63 ± 35.67ms), QTc (436.13 ± 30.70ms vs 435.50 ± 46.97ms) in diabetic patients before and after hypoglycemia were not significantly different. Tp-Te (89.06 ± 16.86ms vs 98.88 ± 23.08 ms P = 0.0325), Tp-Te / QT (0.23 ± 0.07 vs 0.25 ± 0.06, P = 0.0318). CONCLUSION: The increase of Tp-Te interval and Tp-Te / QT in patients with diabetes mellitus during hypoglycemia suggests that the increase of cardiovascular events in patients with diabetes mellitus may be related to abnormal cardiac repolarization during hypoglycemia.