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人乳头状瘤病毒 (HPV)感染在有性活动的男女中极其普遍 ,且与湿疣 (生殖器疣 )和宫颈癌间存在因果关系。有关 HPV复制的遗传学和对 HPV免疫应答的新资料促进了预防性和治疗性 HPV疫苗的研制 ,可望在 5～ 1 0年内获得疫苗。本文概述了HPV的病毒学和流行病学、HPV疫苗及其应用。
Human papillomavirus (HPV) infection is extremely common among men and women with sexual activity and is causally related to genital warts (genital warts) and cervical cancer. New information on the genetics of HPV replication and the immune response to HPV has prompted the development of prophylactic and therapeutic HPV vaccines and is expected to be available within 5 to 10 years. This article provides an overview of HPV virology and epidemiology, HPV vaccines and their applications.