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目的分析机械通气联合固尔苏治疗重症新生儿呼吸衰竭的疗效,并观察其对患者呼吸系统功能恢复影响。方法选取62例重症新生儿呼吸衰竭患儿,采用随机数字表法分为观察组31例和对照组31例,两组均给予机械通气治疗,观察组加用固尔苏治疗,对比两组治疗3 d后总有效率、治疗前和治疗12 h后呼吸系统功能指标[动脉血氧饱和度(Sa O2)、p H值、二氧化碳分压(Pa CO2)、氧分压(Pa O2)、氧合指数(OI)、肺动态顺应性(Cdy)]水平。采用SPSS18.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,计数资料用率(%)表示,采用χ2检验,P<0.05为差异有统计学意义。结果观察组总有效率为93.55%,高于对照组70.97%,差异有统计学意义(χ2=5.415,P<0.05);观察组治疗12 h后Sa O2、p H、Pa O2、OI、Cdy高于对照组,Pa CO2低于对照组,差异均有统计学意义(P<0.05)。结论重症新生儿呼吸衰竭以机械通气联合固尔苏治疗,可改善患儿呼吸系统功能,显著提高治疗效果。
Objective To analyze the curative effect of mechanical ventilation combined with curene on severe neonatal respiratory failure and to observe its effect on the recovery of respiratory system function in patients. Methods Sixty-two infants with severe neonatal respiratory failure were divided into observation group (n = 31) and control group (n = 31) by random number table. Both groups were given mechanical ventilation. After 3 days, the total effective rate, respiratory function index (arterial oxygen saturation (Sa O2), p H value, Pa CO2, Pa O2, oxygen (OI), pulmonary dynamic compliance (Cdy)] levels. Statistical analysis was carried out by using SPSS18.0 statistical software. The measurement data were expressed as mean ± standard deviation (x ± s), t test was used and the count data was used (%), using χ2 test, P <0.05 was statistically significant significance. Results The total effective rate in the observation group was 93.55%, which was higher than that in the control group (70.97%, χ2 = 5.415, P <0.05). After 12 hours of treatment, Sa O2, p H, Pa O2, OI, Cdy Higher than the control group, PaCO2 lower than the control group, the difference was statistically significant (P <0.05). Conclusion Severe neonatal respiratory failure with mechanical ventilation combined with solid Seoul cure, can improve children’s respiratory system function, significantly improve the therapeutic effect.