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血循环中出现因子Ⅷ(FⅧ)抗体,一般发生在甲型血友病。据道导,有5～20％的甲型血友病产生对FⅧ的抑制物。Shapiro报告有5～10％的甲型血友病患者对FⅧ促凝活性(Ⅷ:C)产生抑制物。瑞典有8％的重症甲型血友病循环中有抑制物。抑制物发生的百分率差异很大,为1～21％。抑制物出现可能与接受输血、冷沉淀物或FⅧ浓缩物有关。大多数发生于重型血友病。一旦发生出血,治疗很困难。现将抗FⅧ抗体及其临床处理中的有关问题综述如下:
Factor VIII (F Ⅷ) antibodies appear in the blood circulation, usually occurs in hemophilia A. According to the guide, there are 5 to 20% of hemophilia A produced F VIII inhibitors. Shapiro reports that 5% to 10% of patients with hemophilia A have an inhibitor of FⅧ procoagulant activity (Ⅷ: C). In Sweden, 8% of patients with severe hemophilia A have inhibitors. The percentage of inhibitors varies widely, from 1 to 21%. The presence of inhibitors may be related to receiving blood transfusions, cryoprecipitate, or FVIII concentrates. Most occur in severe hemophilia. In the event of bleeding, treatment is difficult. Now Anti-F Ⅷ antibodies and related issues in clinical treatment are summarized as follows: