论文部分内容阅读
未分化的鼻咽癌(UCNT)是一个对放射和化疗均敏感的恶性肿瘤。传统治疗方法的5年生存率在20％～60％之间,当放射剂量大于60Gy时,局部控制率超过80％,但这种肿瘤大多会出现远处转移。化疗用于UCNT的治疗已有20多年,但由于归纳在头颈部肿瘤中,而没有专门的报道。作者(法,Gustave Roussy研究所)对1985年10月到1986年12月时,49例UCNT使用PBF方案化疗的研究。49例均为复发或远处转移的患者,年龄在16～70岁之间。经检查WBC≥3,000/μl,血小板≥150,000/μl,肌酐清除率≥70ml/min,肌酐水平<120mmol/L,肺功能正常等。给予PBF方案化疗。治疗方法:CDDP 100mg/m~2,第1天,iv,给予水化和甘露醇利尿;BLM15mg第1天,静推,接用16mg/m~2
Undifferentiated nasopharyngeal carcinoma (UCNT) is a malignant tumor that is sensitive to radiation and chemotherapy. The 5-year survival rate of traditional treatment methods is between 20% and 60%. When the radiation dose is greater than 60 Gy, the local control rate exceeds 80%, but most of these tumors will have distant metastases. Chemotherapy has been used for the treatment of UCNT for more than 20 years, but it has not been specifically reported because of its induction in head and neck cancers. The authors (French, Gustave Roussy Institute) studied the use of PBF regimen chemotherapy for 49 UCNTs from October 1985 to December 1986. All 49 patients were recurrent or distant metastatic patients aged between 16 and 70 years old. WBC ≥ 3,000/μl, platelet ≥ 150,000/μl, creatinine clearance ≥ 70ml/min, creatinine level <120mmol/L, normal lung function, etc. Give PBF regimen chemotherapy. Treatment: CDDP 100mg/m~2, on the first day, iv, hydration and mannitol diuresis; BLM15mg on the first day, static push, followed by 16mg/m~2