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目的:探讨止哮平喘方对哮喘大鼠全血和BALF中白细胞和EOS数量的影响。方法:SD大鼠随机分为正常对照组,模型组,地塞米松组,止哮平喘方小、中、大剂量组。采用OVA致敏和激发复制哮喘大鼠模型。测量全血和BALF中白细胞总数及EOS百分率。结果:各治疗组大鼠全血和BALF中白细胞总数、EOS百分率明显下降(P<0.01或P<0.05)。结论:止哮平喘方可以通过减少哮喘大鼠血和气道中白细胞及EOS数量,减轻气道炎症,发挥平喘作用。
Objective: To investigate the effect of “Zhijiao Pingchuan Decoction” on white blood cells and EOS in whole blood and BALF of asthmatic rats. Methods: SD rats were randomly divided into normal control group, model group, dexamethasone group, Zhizhichuan Pingchuan small, medium and large dose groups. Sensitized and challenged OVA-induced asthma rat model. The total white blood cells and percentage of EOS in whole blood and BALF were measured. Results: The total number of white blood cells and the percentage of EOS in whole blood and BALF of rats in each treatment group were significantly decreased (P <0.01 or P <0.05). Conclusion: Zhichao Pingchuan Prescription can relieve airway inflammation and reduce the number of white blood cells and EOS in the blood and airway of asthmatic rats, and play an antiasthmatic effect.