Chiglitazar:a novel pan-PPAR agonist

来源 :科学通报(英文版) | 被引量 : 0次 | 上传用户:hnazlz
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Thiazolidinediones(TZDs)are potent insulin sensitizers[1,2],effectively lower the glycosylated hemoglobin A1c HbA1c[1,3]and exert cardiovascular(CV)protective effects in diabetic[4]and nondiabetic[5]individuals with a prior CV event.Although less well appreciated TZDs also enhance beta cell function[6].
其他文献
The Tibetan Plateau is characterized by extreme weather,harsh environment,and high sensitivity to climate warming and human activities[1].Once degraded,it is difficult to rehabilitate the ecosystems in this region because of the unique environment.Con-seq
期刊
The Loess Plateau (LP) is an ecologically fragile region due to its sensitivities to climate variations and anthropogenic influences [1].The Chinese government recognized the ecological significance of the LP and implemented a series of ecological restora
期刊
The uplift of different parts of the Tibetan Plateau caused by the collision,subduction and thickening of the Indian-Eurasian conti-nent is considered to be the most significant landform change of Asia in the last 50 Ma.The plateau uplift led to elevation
期刊
The Tibetan Plateau(TP),as the world\'s highest plateau,has almost all the key elements of the entire Earth system,including interconnected lithosphere,atmosphere,cryosphere,biosphere and anthroposphere[1-3].This completeness makes the TP an ideal natur
期刊
Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer and essential for metabolism in malignancies,but its regulation and modulation in cancer cells remain poorly understood.Here,using large-scale functional screening,we identified a
The security of quantum communication is based on the laws of quantum mechanics,which can resist attacks from any powerful classical and quantum computers.It has great potential in secure communication in the future.One well-known form of quantum communic
期刊
Metal halide perovskite solar cells(PSCs)have drawn enormous attention due to their great potential to share the market of silicon solar cells[1-3].During the past few years,significant progress has been made in fabrication method,chemical composition,def
期刊
The orchestrated expression of thousands of genes gives rise to the complexity of the human brain.However,the structures governing these myriad gene-gene interactions remain unclear.By analyzing transcription data from more than 2000 sites in six human br
Introducing ferromagnetism into non-magnetic systems without the participation of magnetic elements is promising for all-electric spintronic devices[1,2].Many approaches have been pursued,such as non-magnetic defects induced magnetization in layered mater
期刊
The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a high number of deaths in the world.To combat it,it is necessary to develop a better understanding of how the virus infects host cells.Infection normally starts w