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1987年后期,维甲酸受体(RAR)被确定为类固醇/甲状腺激素受体族中的成员,这一发现是维甲酸研究领域的重大突破。作者综述了 RAR 目前的研究状况,并且就合成维甲酸对人类皮肤作用机制的许多新的可能性进行了探讨。人类维甲酸受体属核受体族 RAR 是一种对维甲酸(RA)有高度亲合力的分子量为48～54kD 的蛋白质,它与类固醇激素、甲状腺激素和 VitD3的受体有同源性,似乎是一种 RA 可诱导的转化活动增强因子(transacting enhancer factor),即在结合 RA 时对靶基因进行调节。人们按以下三个步骤对上述事实进行了验证。
In late 1987, Retinoic Acid Receptor (RAR) was identified as a member of the steroid/thyroid hormone receptor family, a discovery that was a major breakthrough in the field of retinoids research. The author reviews the current state of RAR research and discusses many new possibilities for the synthesis of retinoic acid on human skin. Human RTR receptor nuclear receptor RAR is a protein with a high affinity for retinoic acid (RA) and has a molecular weight of 48-54 kD. It has homology with steroid hormones, thyroid hormone and VitD3 receptors. It appears to be a RA-inducible transacting enhancer factor, which regulates the target gene when it binds to RA. People have verified these facts in the following three steps.