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目的研究肝内胆汁淤积症(ICP)孕妇伴胆红素升高与围产儿预后的关系。方法选择2008年1月至2010年12月该院住院分娩的ICP孕妇伴胆红素水平升高21例为治疗组,ICP孕妇胆红素水平正常56例为对照组,比较两组围产儿的预后。结果治疗组围产儿羊水胎粪污染、胎儿窘迫、早产、新生儿窒息及死胎(死产)的发生率分别为61.90%、28.57%、9.52%、14.29%、4.76%,均高于对照组(P<0.05)。结论 ICP孕妇胆红素水平升高者围产儿不良结局的发生率明显较高。
Objective To study the relationship between elevated bilirubin in pregnant women with intrahepatic cholestasis (ICP) and the prognosis of perinatal infants. Methods From January 2008 to December 2010, the ICP pregnant women hospitalized for delivery of the hospital with bilirubin levels increased 21 cases for the treatment group, ICP pregnant women with normal bilirubin 56 cases as control group, compared two groups of perinatal Prognosis. Results The incidence of perinatal meconium-stained amniotic fluid, fetal distress, premature birth, neonatal asphyxia and stillbirth in the treatment group were 61.90%, 28.57%, 9.52%, 14.29% and 4.76%, respectively, higher than those in the control group P <0.05). Conclusion The incidence of adverse outcomes of perinatal children with elevated ICP bilirubin in ICP pregnant women is significantly higher.