目的探讨HPV-DNA基因分型检测在CIN患者术后随访中的临床应用价值。方法选取确诊并治疗的CIN患者,术前行HPV-DNA基因分型检测,之后按诊治规范施术。在治疗后再次进行HPV-DNA基因分型检测。结果 134例接受手术的CIN患者,术后随访0.5~1.5年,2例术后病变残留;10例病变复发,Logistic回归分析显示,术后同一型HPV持续感染为CIN术后复发的危险因素,而年龄、切缘阳性、CIN分级、是否累腺与术后复发无相关性。结论同一型HPV持续感染为CIN术后复发的危险因素,HPV-DNA基因分型检测对于CIN患者术后随访具有重要的临床意义。 Objective To investigate the clinical value of HPV-DNA genotyping in the follow-up of CIN patients. Methods The patients with CIN diagnosed and treated were selected and HPV-DNA genotyping was performed preoperatively, followed by diagnosis and treatment. HPV-DNA genotyping was again performed after treatment. Results Of the 134 CIN patients undergoing surgery, the patients were followed up for 0.5 to 1.5 years. The remaining 2 lesions remained after operation. The recurrence of 10 lesions showed that the persistent infection of the same type of HPV was the risk factor of recurrence after CIN. The age, positive margins, CIN grading, whether the nemesis associated with postoperative recurrence. Conclusion Persistent infection of the same type of HPV is a risk factor for recurrence of CIN. HPV-DNA genotyping has important clinical significance for follow-up of patients with CIN.