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目的研究1例不规则抗体筛查阳性的产妇及其新生儿发生新生儿溶血病的原因。方法通过临床资料分析,红细胞血型鉴定、新生儿直接抗球蛋白试验、血清抗体筛查、抗体鉴定、抗体效价测定等血型血清学检测产妇及新生儿血清中的抗体,找到相配合的血液给新生儿换血治疗。结果产妇血清、新生儿血清及红细胞放散液中均检测到抗-E、c和抗-S,测得产妇血清中抗-E的效价为32;抗-c效价为32;抗-S效价为2。筛选4份E(-)、c(-)的血与新生儿血清进行交叉配血均相合,经验证此4份血样S抗原为阴性。结论发现1例抗-E、c和抗-S多抗体引起的母婴血型不合新生儿溶血病,及时为新生儿提供了相匹配的血液。
Objective To investigate the causes of neonatal hemolytic disease in one mothers and their newborns with positive antibody screening. Methods The serums of maternal and newborn were detected by blood group serology in clinical data analysis, erythrocyte blood group identification, neonatal direct antiglobulin test, serum antibody screening, antibody identification and antibody titer determination to find the matched blood Neonatal transfusion therapy. Results Anti-E, c and anti-S were detected in maternal serum, neonatal serum and erythrocyte discharge. The titers of anti-E in maternal serum were 32; anti-c titers were 32; anti-S The titer is 2. Screening 4 copies of E (-), c (-) blood and neonatal serum cross matching blood are consistent, the four blood samples proved to be S antigen negative. Conclusion One case of neonatal hemolytic disease caused by anti-E, C and anti-S polyclonal antibodies was found to provide neonatal matched blood in time.