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利用16O(p ,α) 13 N核反应 ,经戴氏合金 (Devarda’salloy)还原靶水制备出13 N -NH3 ·H2 O的生理盐水注射液。标记产物利用TLC、HPLC进行放射化学分析 ,放化纯度 >95 % ,放射性浓度为(1.11— 2 .2 2 )GBq/mL。小鼠分布实验显示心肌摄取率最高 ,平均 %ID/g为 19.5 4 % ;首次通过时 ,心肌和肺的摄取率最高 ,其 %ID/g各为 2 4 .90± 1.82和 2 2 .79± 1.94 ,约有 92 %的放射性从血液中清除 ;注射后 1min ,各器官中的放射性急剧下降 ,5min时下降到最低值 ,10min时各器官中的放射性又明显升高 ,在 1— 30min内 ,心脏摄取稳定在 11.34%— 2 9.2 4 %。13 N -NH3 ·H2 O有较高的心 /肝和心 /肺比值和较快的血液清除率。结果表明 ,Devarda’salloy还原法是一种简单快速、可获得较高核纯度和放化纯度的13 N -NH3 ·H2 O的制备方法。小鼠分布实验提示在静脉注射13 N-NH3 ·H2 O后 2— 5min内进行PET显像 ,可获得满意的图象。
The 13N -NH3 · H2O physiological saline solution was prepared by the 16O (p, α) 13N nuclear reaction and the target water was reduced by Devarda’s salloy. The labeled product was subjected to radiochemical analysis by TLC, HPLC with radiochemical purity> 95% and radioactive concentration (1.11-2.22) GBq / mL. The distribution of mice showed the highest myocardial uptake rate, with an average% ID / g of 19.5 4%. The highest uptake rate of myocardium and lung at the first passage was 24.990 ± 1.82 and 2.27 ± 1.94, about 92% of the radioactivity was cleared from the blood; 1 min after injection, the radioactivity in various organs dropped sharply and dropped to the lowest level at 5 min. The radioactivity in each organ was significantly increased at 10 min. Within 1-30 min , Cardiac intake stabilized at 11.34% - 2 9.2 4%. 13 N-NH 3 .H 2 O has higher heart / liver and heart / lung ratios and faster blood clearance. The results show that the Devarda’s alloy reduction method is a simple and rapid method for the preparation of 13 N -NH 3 .H 2 O with higher nuclear purity and radiochemical purity. Mouse distribution experiments suggest that PET imaging can be performed within 2-5 min after intravenous injection of 13 N-NH3 · H2 O to obtain a satisfactory image.