论文部分内容阅读
目的:测定大鼠血浆及组织中苦参碱的浓度,研究大鼠静脉给药后苦参碱溶液(MS)、苦参碱脂质体(ML)和苦参碱隐形脂质体(LML)的药代动力学规律及组织分布特征。方法:采用反相高效液相色谱法测定大鼠血浆和组织中的苦参碱浓度。结果:MS、ML和LML的药代动力学行为符合二房室模型;LML的半衰期是MS的2.7倍,是ML的2倍;LML的药时曲线下面积(AUC)是MS的63倍,是ML的2.3倍;LML在血浆中的AUC值相对于ML和MS具有显著性差异(P<0.05);LML在肝脏、脾脏中的AUC值相对于ML具有显著性差异(P<0.05);LML的Blood/RES是ML的5.4倍。结论:LML明显改变苦参碱在大鼠血浆中的药代动力学特征和组织中的靶向定位特征。
Objective: To determine the concentration of matrine in rat plasma and tissues, and to study matrine solution (MS), matrine liposomes (ML) and matrine invisible liposomes (LML) after intravenous administration in rats. The pharmacokinetics and tissue distribution characteristics of the pharmacokinetics. METHODS: The concentrations of matrine in plasma and tissues were determined by reversed-phase high performance liquid chromatography. Results: The pharmacokinetic behavior of MS, ML, and LML was consistent with a two-compartment model; the half-life of LML was 2.7 times that of MS and twice that of ML; the area under the drug-time curve (AUC) of LML was 63 times that of MS. 2.3 times of ML; the AUC value of LML in plasma was significantly different from that of ML and MS (P<0.05); the AUC value of LML in liver and spleen was significantly different from that of ML (P<0.05); LML The Blood/RES is 5.4 times that of ML. CONCLUSIONS: LML significantly alters the pharmacokinetic profile of matrine in plasma and the targeted localization characteristics in tissues.