鼠疫是自然疫源性疾病,20世纪上半叶,世界鼠疫流行十分猖獗。1901~1910年60多个国家和地区发生鼠疫病例5459784人;20世纪中叶,人间鼠疫病例明显下降,60~80年代,只在20多个国家有鼠疫病例报告;进入90年代,人间病例则又呈上升趋势[1]。鼠疫病原学和血清学检验是鼠疫自然疫源地监? Plague is a natural epidemic disease. In the first half of the 20th century, the world plague epidemic was rampant. From 1901 to 1910, there were 5,459,784 plague cases in more than 60 countries and regions. In the mid-20th century, the incidence of human plague was significantly reduced. In the 1960s and 1980s, plague cases were reported in more than 20 countries. In the 1990s, inter-human cases were An upward trend [1]. Plague etiology and serological tests are plague natural foci to monitor?