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应用放射性同位素(RI)或RI 标记化合物作为示踪剂,进行肝胆道功能检查始于1955年,由Taplin 氏首先在临床上试用。方法是将~(131)碘—玫瑰红(~(131)I—Rosebengal RB)静脉注入体内后,从体外用闪烁计数器测定肝摄取或排出之放射性强度,即“肝放射图”。有的用测定血中~(131)I—RB 残存率来评价肝脏功能;此后,曾应用~(131)碘—磺溴酞钠(~(131)I—BSP),以闪烁扫描或闪烁照相动态地进行腹部照相,即“肝胆显像”。近年来,随着核仪器的发展,临床上广泛研制出适用于快速显像的短半衰期99~m 锝(99~mTc)—标记化合物。1.原理及方法
The use of radioactive isotopes (RI) or RI-labeled compounds as tracers for hepatobiliary function tests began in 1955 and was first clinically tested by Taplin. The method was to intravenously inject ~131 iodine-rose red (131I-Rosebengal RB) into the body, and the radioactivity of liver uptake or excretion was measured by a scintillation counter in vitro, ie, “liver radiograph”. Some used the determination of the residual rate of 131 I-RB in the blood to evaluate liver function; thereafter, 131 iodide-sodium bromide (131 I-BSP) was applied to scintigraphy or scintigraphy. Abdominal photography is performed dynamically, ie, “hepatobiliary imaging.” In recent years, with the development of nuclear instruments, a short half-life 99 ~ m 锝 (99~mTc)-labeled compound has been widely developed for rapid imaging. 1. Principle and method