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目的观察乳腺癌术前化疗的临床和病理改变，判断药物疗效，指导术后治疗。方法对术前化疗手术标本进行ＨＥ、免疫组织化学染色观察。结果和术前未化疗的对照组相比，乳腺癌化疗后出现瘤体变软缩小、肿瘤细胞退变坏死、间质水肿、血管周围炎症细胞浸润及异物肉芽肿形成等改变；免疫组织化学显示ＰＣＮＡ、ＣｅｒｂＢ２蛋白阳性表达明显降低。ＥＲ、ＰＲ表达无显著差异。结论乳腺癌术前化疗在降低肿瘤细胞增殖活力，使瘤体缩小，增加乳腺癌保守治疗机会等方面具有重要作用
Objective To observe the clinical and pathological changes of preoperative chemotherapy for breast cancer, determine the efficacy of the drug, and guide postoperative treatment. Methods HE and immunohistochemical staining were performed on preoperative chemotherapy specimens. Results Compared with the pre-chemotherapy control group, tumors became softer and smaller, necrosis of tumor cells, interstitial edema, infiltration of perivascular inflammatory cells, and formation of foreign body granuloma after chemotherapy in breast cancer; immunohistochemistry showed that The positive expression of PCNA and CerbB2 protein was significantly reduced. There was no significant difference in the expression of ER and PR. Conclusion Preoperative chemotherapy for breast cancer plays an important role in reducing the proliferation of tumor cells, shrinking tumors, and increasing the chance of conservative treatment of breast cancer.