论文部分内容阅读
近几年来,国内外不少药学工作者实验研究了磺胺嘧啶片的体外溶出速度和体内生物利用度,并找出了一些规律。Garnham等试验了不同磺胺嘧啶片处方对其生物利用度的影响。Ritschel等通过不同品种和不同用量的粘合剂对磺胺嘧啶片释放度影响的研究,观察到除聚乙烯吡咯烷酮外,其它所试验的四种粘合剂均表现为:增加用量,则降低溶出速度。Ahmed等试验观察了用量为0～0.5％的硬脂酸镁对磺胺嘧啶片溶出速度的影响,而得出增加硬脂酸镁浓度,则增加崩解时间、降低溶出速度的结论。Erni等和Ritschel等还分
In recent years, many domestic and foreign pharmaceutical workers experimentally studied the dissolution rate of sulfadiazine tablets in vitro and in vivo bioavailability, and found some rules. Garnham et al. Tested the effects of different sulfadiazine tablets on their bioavailability. Ritschel and so on through different varieties and different amount of adhesive on the release of sulfadiazine tablets, the study observed that in addition to polyvinylpyrrolidone, the other four tested binders are shown: increased dosage, then reduce the dissolution rate . Ahmed and other experiments observed the amount of 0 ~ 0.5% magnesium stearate sulfadiazine tablets dissolution rate, and draw increased magnesium stearate concentration, increase the disintegration time, reduce the dissolution rate conclusion. Erni et al. And Ritschel et al