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目的观察低剂量沙利度胺加地塞米松治疗难治性多发性骨髓瘤的疗效。方法低剂量沙利度胺加地塞米松治疗难治性多发性骨髓瘤24例,治疗方法用沙利度胺初始剂量100～200mg/d,晚上1次顿服,从100mg开始的患者过2周加量至200mg,以后维持在200mg,地塞米松给予5mg/次,2次/d,口服,二药联合低剂量应用,持续12周。12周后进行化疗1个疗程,12周为1个周期。结果 2个周期治疗后有11例部分缓解,7例进步,6例无效。其中3例加重。总有效率75%。结论低剂量沙利度胺加地塞米松治疗难治性多发性骨髓瘤疗效确切,不良反应少。
Objective To observe the effect of low dose thalidomide combined with dexamethasone in the treatment of refractory multiple myeloma. Methods 24 cases of refractory multiple myeloma were treated with low dose thalidomide plus dexamethasone. The initial dose of thalidomide was 100-200 mg / d, once a night, and the dosage of thalidomide was 100% To 200mg, later maintained at 200mg, dexamethasone given 5mg / time, 2 times / d, oral, two drugs combined with low-dose application for 12 weeks. After 12 weeks of chemotherapy for a course of treatment, 12 weeks for a cycle. Results After 2 cycles of treatment, 11 patients were partially relieved, 7 patients improved, and 6 patients were ineffective. Three of them exacerbated. The total effective rate of 75%. Conclusion Low-dose thalidomide plus dexamethasone is effective in the treatment of refractory multiple myeloma with few adverse reactions.