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腹泻是胃肠道疾病常见症状之一,全世界统计每天约有2亿的腹泻患者;亚非拉地区5岁以下的儿童患腹泻者,每年达5亿之多.该地区估计每年有500万～1000万人死于腹泻;腹泻也是许多国家造成劳动力丧失的重要原因.虽然细菌、病毒、原虫感染是急、慢性腹泻的主要病因,并有针对病因的特效药物,但止泻药的种类仍不多.常见的抗胆碱能药和吗啡类及其衍生物,因其副作用限制了它的临床应用.近10年来,根据肠道生理学的研究,对肠道吸收和分泌的机制有较大进展,而把各种不同原因引起的腹泻分为三种:1.分泌性腹泻:临床中各种胃肠道感染,细菌毒素、消化道激素、胆酸、长链脂肪酸和一些缓泻剂均可通过激活肠粘膜细胞内的cAMP系统,使
Diarrhea is one of the most common symptoms of gastrointestinal diseases, with an estimated 200 million diarrhea patients worldwide every day; diarrhea in children up to the age of 5 in Asia, Africa and Latin America reaches more than 500 million annually, and the area is estimated at 5 million ~ 10 million people die of diarrhea and diarrhea is also an important cause of labor loss in many countries.Although bacteria, viruses and protozoa are the main causes of acute and chronic diarrhea with specific drugs for the cause, the types of antidiarrheal drugs are still not And more common anticholinergic drugs and morphine and its derivatives, because of its side effects limit its clinical application of the past 10 years, according to intestinal physiology research, the intestinal absorption and secretion of the mechanism has made great progress , And diarrhea caused by a variety of different causes are divided into three types: 1. Secretory diarrhea: a variety of clinical gastrointestinal infections, bacterial toxins, gastrointestinal hormones, cholic acid, long chain fatty acids and some laxatives can be passed Activate the cAMP system in the intestinal mucosa