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目的检测中国广东地区汉族人群中类风湿关节炎(RA)发病与蛋白酪氨酸磷酸酶非受体型22(PTPN22)基因Arg620Trp/1858C>T多态性的关系。方法采用PCR-RFLP技术分析了广东汉族人群中148例散发RA患者和150例健康对照者PTPN22 1858位点基因型。结果在中国广东地区汉族人群中PTPN22 1858位点仅存在等位基因C,与RA的发病无关。结论中国广东地区汉族人群中,PTPN22 Arg620Trp多态性与RA的发病无关;PTPN22基因可能存在其他多态性位点,需作进一步探讨。
Objective To examine the association between the incidence of rheumatoid arthritis (RA) and the Arg620Trp / 1858C> T polymorphism of the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene in Chinese Han population of Guangdong province in China. Methods The genotypes of PTPN22 1858 in 148 cases of RA patients and 150 healthy controls were analyzed by PCR-RFLP in Guangdong Han population. Results There was only allele C in PTPN22 1858 locus in Han population in Guangdong province of China, which was not associated with the pathogenesis of RA. Conclusion There is no association between the PTPN22 Arg620Trp polymorphism and the incidence of RA in Chinese Han population in Guangdong, China. There may be other polymorphic sites of PTPN22 gene, which need to be further explored.