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目的探讨去整合素-金属蛋白酶17(ADAM17)蛋白在食管鳞癌中表达及其与临床病理因素的相关性。方法采用Western blot和IHC方法检测50例食管鳞癌(A组)及对应的正常食管黏膜(C组)中ADAM17蛋白的表达。结果 A组ADAM17蛋白的表达量为0.887±0.174,表达阳性率为66%(33/50),均明显高于C组的0.273±0.081和6%(3/50)(P<0.01)。食管鳞癌中ADAM17蛋白的表达量与淋巴结转移、TNM分期呈正相关(P<0.05),但与性别、年龄及组织学分级无相关性(P>0.05)。结论 ADAM17蛋白在食管鳞癌中高表达,在食管癌的发生、侵袭转移中起重要作用,对判断食管癌患者预后有一定的价值。
Objective To investigate the expression of integrin - metalloproteinase 17 (ADAM17) in esophageal squamous cell carcinoma and its relationship with clinicopathological factors. Methods Western blot and IHC were used to detect the expression of ADAM17 protein in 50 esophageal squamous cell carcinomas (group A) and corresponding normal esophageal mucosa (group C). Results The expression of ADAM17 protein in group A was 0.887 ± 0.174 and the positive rate was 66% (33/50), which were significantly higher than those in group C (0.273 ± 0.081 and 6%, 3/50 respectively) (P <0.01). The expression of ADAM17 in esophageal squamous cell carcinoma was positively correlated with lymph node metastasis and TNM stage (P <0.05), but not with gender, age and histological grade (P> 0.05). Conclusion ADAM17 protein is overexpressed in esophageal squamous cell carcinoma and plays an important role in the occurrence, invasion and metastasis of esophageal carcinoma. It has certain value in judging the prognosis of esophageal cancer patients.