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目的观察早期尿激酶静脉溶栓治疗急性心肌梗塞（ＡＭＩ）的疗效及冠状动脉（冠脉）再通与早期Ｔ波倒置的相关性。方法回顾分析３４例ＡＭＩ患者采用早期尿激酶溶栓治疗与５７例ＡＭＩ患者的常规治疗作对照，观察溶栓治疗患者的再通情况及其溶栓后 ２４ ｈ内 Ｔ波倒置对判定冠脉再通的意义。结果尿激酶治疗组和对照组的冠脉再通率分别为６４．７１％和１５．７９％（Ｐ＜０．０５），发病至开始溶栓时间越短，再通率越高。早期溶栓后 ２４ ｈ内 Ｔ波倒置显示冠脉再通的敏感性和特异性分别为９０．４８％和７６．９２％。结论早期尿激酶静脉溶栓治疗可提高急性心肌梗塞疗效，降低病死率。Ｔ波倒置具有判断闭塞冠脉再通的临床价值。
Objective To observe the curative effect of early intravenous urokinase thrombolytic therapy on acute myocardial infarction (AMI) and the correlation between coronary recanalization and early T wave inversion. Methods Retrospective analysis of 34 cases of AMI patients with early urokinase thrombolytic therapy and 57 cases of AMI in patients with routine treatment as the control to observe the recanalization of patients with thrombolysis and 24 hours after thrombolytic T wave inversion to determine the coronary artery and then The meaning of pass. Results The rates of coronary recanalization in the urokinase treated group and the control group were 64.71% and 15.79%, respectively (P <0.05). The shorter the initial thrombolysis time and the higher the recanalization rate. The sensitivity and specificity of T wave inversion within 24 hours after early thrombolysis were 90.48% and 76.92% respectively. Conclusion Early intravenous urokinase thrombolytic therapy can improve the efficacy of acute myocardial infarction and reduce mortality. T wave inversion has the clinical value of judging occlusion of coronary recanalization.