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本世纪六十年代戊脉安、心可定、脑益嗪问世时,它们分别作为β-肾上腺素能受体阻滞剂、儿茶酚胺摄入阻滞剂和抗组胺药。但到六十年代末,它们被认为是钙内流阻滞剂,由于Fleckenstain等的工作,出现了“钙拮抗作用”这一个新的药理学原理。七十年代初,这类钙拮抗剂因硝苯啶和硫氮(艹卓)酮的出现而有所扩展,并发现钙拮抗剂作为研究依赖钙的过程的实验工具和治疗各种心血管疾病如心绞痛和高血压的有效药物,均有重要作用。这些钙拮抗剂化学结构虽不同,但钙拮抗作用相似。尽管某些研究者认为有些拮抗
In the sixties of this century, verapamil, heart can be set, brain Yizhen come out, they were as β-adrenergic receptor blockers, catecholamine intake blockers and antihistamines. However, by the late 1960s they were considered as calcium influx blockers and due to the work of Fleckenstain et al., A new pharmacological principle of “calcium antagonism” emerged. In the early seventies, such calcium antagonists were expanded by the appearance of nifedipine and sulfanilamide and found that calcium antagonists were used as experimental tools in the study of calcium-dependent processes and in the treatment of various cardiovascular diseases Effective drugs such as angina pectoris and high blood pressure play an important role. Although the chemical structure of these calcium antagonists is different, but the role of calcium antagonists similar. Although some researchers think it is somewhat antagonistic