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目的评价左乙拉西坦片治疗多发性抽动秽语综合征伴临床下放电患儿的疗效和安全性。方法对左乙拉西坦片治疗的11例多发性抽动秽语综合征伴临床下放电患儿进行自身对照随访研究,分析其临床治疗效果及不良反应发生情况。结果左乙拉西坦片治疗随访6个月以上,总有效率为90.9%(10/11),不良反应包括乏力9.1%(1/11),嗜睡9.1%(1/11),皮疹9.1%(1/11)。上述不良反应均为一过性,在1～4周内自然消失或减量后消失,未导致停药。结论左乙拉西坦片用于多发性抽动秽语综合征伴临床下放电患儿不仅能较好地控制抽动症状,而且能控制临床下放电,疗效肯定、安全性好。
Objective To evaluate the efficacy and safety of levetiracetam tablet in the treatment of children with multiple Tourette’s syndrome with clinical discharge. Methods Eleven cases of multiple glaucomatous syndrome treated with levetiracetam with self-control follow-up study were performed to analyze the clinical effect and the incidence of adverse reactions. Results Levetiracetam tablets were followed up for 6 months or more, with a total effective rate of 90.9% (10/11). Adverse reactions included fatigue 9.1% (1/11), drowsiness 9.1% (1/11), rash 9.1% (1/11). The adverse reactions are transient, disappear after 1 to 4 weeks of natural or reduced, did not lead to withdrawal. Conclusion Levetiracetam tablets for children with multiple Tourette’s syndrome with clinical discharge not only can better control tic symptoms, but also can control the clinical discharge, positive effect, good safety.