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目的观察缬沙坦对原发性高血压患者并发左心室肥厚(LVH)的影响。方法84例原发性高血压合并左心室肥厚患者随机分成治疗组与对照组,治疗组口服缬沙坦一日80～160mg,对照组口服硝苯地平片10mg日3次;服药前和服药后24、36周,由超声测量左心室的结构变化。结果治疗组患者血压由(159.0±17.8)/(102.8±11.2)mmHg降为24周时(132.0±12.6)/(84.9±7.2)mmHg,36周时(129.0±11.1)/(82.5±5.7)mmHgP<0.05;对照组患者血压由(160.2±10.1)/(104.8±10.2)mmHg降为24周时(139.0±12.1)/(87.5±6.7)mmHg,36周时降为(129.3±12.4)/(81.5±6.8)mmHgP<0.05。治疗组左室重量指数由(147.1±27.6)g/m2降至24周时(140.3±21.7)g/m2,36周时(138.9±20.9)g/m2;对照组左室重量指数由(148.2±21.5)g∕m2降至24周时(146.5±22.1)g/m2,36周时(145.8±21.0)g/m2。两组间有差异P<0.05。结论缬沙坦与硝苯地平片在有效降低血压的同时,缬沙坦可逆转左心室肥厚优于硝苯地平片。
Objective To observe the effect of valsartan on left ventricular hypertrophy (LVH) in patients with essential hypertension. Methods Eighty-four patients with essential hypertension and left ventricular hypertrophy were randomly divided into treatment group and control group. The treatment group received valsartan 80-80 mg on the 1st day while the control group took nifedipine 10 mg for 3 times daily. Before and after taking the drug, 24, 36 weeks, left ventricular structural changes measured by ultrasound. Results The blood pressure in the treatment group decreased from (159.0 ± 17.8) / (102.8 ± 11.2) mmHg to (132.0 ± 12.6) / (84.9 ± 7.2) mmHg at 24 weeks and (129.0 ± 11.1) / (82.5 ± 5.7) at 36 weeks mmHgP <0.05. The blood pressure of the control group decreased from (160.2 ± 10.1) / (104.8 ± 10.2) mmHg to (139.0 ± 12.1) / (87.5 ± 6.7) mmHg at 24 weeks and decreased to (129.3 ± 12.4) / (81.5 ± 6.8) mmHgP <0.05. The left ventricular mass index in the treatment group decreased from (147.1 ± 27.6) g / m2 to (140.3 ± 21.7) g / m2 at 24 weeks and (138.9 ± 20.9) ± 21.5) g / m2 to 146.5 ± 22.1 g / m2 at 24 weeks and 145.8 ± 21.0 g / m2 at 36 weeks. Differences between the two groups P <0.05. Conclusion Valsartan and nifedipine tablets can effectively reduce blood pressure, valsartan can reverse left ventricular hypertrophy better than nifedipine tablets.