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目的探讨新辅助治疗对进展期直肠癌手术及术后的影响,为进展期直肠癌的治疗提供参考。方法选择2013年1月-2 0 1 4年1月在鹤岗市鹤岗矿业集团公司总医院进行手术治疗的2 4例进展期直肠癌患者为观察对象,随机将2 4例患者分成观察组与对照组,每组1 2例,对照组采取常规的手术治疗,观察组在手术前进行常规放化疗,放化疗后采取手术治疗,比较2组患者的术中基本资料(肿瘤切除率,保肛率,术中输血率)和术后并发症发生率。同时对2组患者进行1年的随访,比较2组患者的复发率。结果观察组的术中输血率明显低于对照组,差异有统计学意义(P<0.0 1)。观察组的肿瘤切除率,保肛率明显高于对照组,差异有统计学意义(P<0.0 1)。对照组的并发症发生率明显高于观察组,差异有统计学意义(P<0.0 1)。观察组的复发率明显低于对照组,差异有统计学意义(P<0.0 1)。结论新辅助治疗可减少进展期直肠癌患者的术中输血率,提高肿瘤切除率,降低并发症发生率及短期复发率,可在临床推广应用。
Objective To investigate the effect of neoadjuvant therapy on the operation and postoperative prognosis of advanced rectal cancer and provide reference for the treatment of advanced rectal cancer. METHODS: Twenty-four patients with advanced colorectal cancer undergoing surgical treatment at Hegang Hegang Mining General Hospital from January 2013 to January 2014 were selected as observation subjects and 24 cases were randomly divided into observation group And control group, each group of 12 cases, the control group to take the conventional surgical treatment, the observation group before surgery conventional radiotherapy and chemotherapy, radiotherapy and chemotherapy after surgery, compared the two groups of patients basic information (tumor resection rate, Paul Anal rate, intraoperative blood transfusion rate) and postoperative complications. At the same time, two groups of patients were followed up for 1 year, and the recurrence rate was compared between the two groups. Results The intraoperative blood transfusion rate in the observation group was significantly lower than that in the control group, with significant difference (P <0.01). The tumor resection rate and anal sphincter preservation rate in the observation group were significantly higher than those in the control group (P <0.01). The incidence of complications in the control group was significantly higher than the observation group, the difference was statistically significant (P <0.0 1). The recurrence rate of the observation group was significantly lower than that of the control group, the difference was statistically significant (P <0.0 1). Conclusion Neo-adjuvant therapy can reduce the intraoperative blood transfusion rate, improve tumor resection rate, reduce the incidence of complications and short-term recurrence rate in patients with advanced rectal cancer, which can be popularized and applied clinically.