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目的:分析我国不同海拔地区新生儿脉搏血氧饱和度（SpOn 2）的分布，为不同海拔地区新生儿先天性心脏病（NCHD）筛查提供参考依据。n 方法:基于国家NCHD筛查项目数据库，描述0~100 m、600~700 m、900~1 100 m、1 400~1 600 m、1 900~2 100 m和2 200~2 500 m海拔地区26 766名新生儿SpOn 2的分布，并采用单因素方差分析比较不同海拔地区新生儿SpOn 2的差异。n 结果:0~100 m、600~700 m、900~1 100 m、1 400~1 600 m、1 900~2 100 m和2 200~2 500 m海拔地区新生儿右手的SpOn 2分别为97.7%±1.4%、97.1%±1.1%、96.1%±1.3%、96.0%±1.7%、95.9%±1.7%和95.5%±2.4%，任意一足的均SpOn 2分别为97.7%±1.4%、96.9%±1.1%、96.3%±1.4%、96.0%±1.7%、95.6%±1.8%和95.2%±2.7%。不同海拔地区间新生儿的平均SpOn 2值两两比较差异均有统计学意义（右手：n F=1 248.35，n P<0.001；任意一足：n F= 1 280.45，n P<0.001）。随着海拔高度的升高，新生儿右手和任意一足的SpOn 2呈线性降低趋势（均n P-trend<0.001）。n 结论:随着海拔的升高，新生儿SpOn 2呈降低趋势，提示目前基于海平面地区SpOn 2的NCHD筛查阈值范围可能不适用于更高海拔地区的新生儿。n “,”Objective:To analyze the distribution and variance of neonatal pulse oxygen saturation (SpOn 2) at different altitudes in China, and provide a new evidence for the screening of NCHD at high altitudes.n Methods:Based on the database of National Screening Project of NCHD, the distribution of SpOn 2 values was described in 26 766 newborns at altitudes of 0-100 m, 600-700 m, 900-1 100 m, 1 400-1 600 m, 1 900-2 100 m, and 2 200-2 500 m. One-way analysis of variance was used to analyze the differences among SpOn 2 values in newborns at different altitudes.n Results:The average SpOn 2 values of right hand in newborns at altitudes of 0-100 m, 600-700 m, 900-1 100 m, 1 400-1 600 m, 1 900-2 100 m and 2 200-2 500 m were 97.7%±1.4%, 97.1%±1.1%, 96.1%±1.3%, 96.0%±1.7%, 95.9%±1.7% and 95.5%±2.4%, respectively. And corresponding average SpOn 2 values of either foot were 97.7%±1.4%, 96.9%±1.1%, 96.3%±1.4%, 96.0%±1.7%, 95.6%±1.8% and 95.2%±2.7%, respectively. There were statistically significant differences in the average SpOn 2 values of newborns at different altitudes (right hand: n F=1 248.35, n P<0.001; either foot:n F=1 280.45, n P<0.001). The SpOn 2 of newborns tended to be lower with the increase of altitudes (n P-trend<0.001).n Conclusion:SpOn 2 values in newborns were negatively associated with the altitudes, which indicated that the cut‐off value of screening for NCHD at sea level might not be applicable to newborns at higher altitudes. Thus, it is worthwhile to conducted studies on the normal values of SpOn 2 and the cut‐off value of screening for NCHD in newborns at high altitudes.n