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1943年由Liu和Chu首次报告肾病性骨营养不良。这是一种慢性肾功能衰竭的并发症,常发生于儿童期并导致发育停滞。小儿肾病性骨营养不良的临床表现有发育迟缓、骨痛、肌病、骨骼畸形、婴儿佝偻病。血液生化改变有血清碱性磷酸酶(AP)活性升高、血清甲状旁腺激素(PTH)浓度增加、血清1,25-(OH)_2-D_3降低。X线下可见骨膜下吸收、骨骺滑脱、骨质疏松和佝偻病骨像。病理检查可见骨软化和纤维性骨炎。关于肾病性骨营养不良的发病机理尚未完全明
Nephrotic osteodystrophy was first reported by Liu and Chu in 1943. This is a complication of chronic renal failure, often in childhood and leads to developmental arrest. Clinical manifestations of pediatric nephrogenic osteodystrophy are stunting, bone pain, myopathy, skeletal deformities, and infant rickets. Blood biochemical changes have increased serum alkaline phosphatase (AP) activity, serum parathyroid hormone (PTH) concentration increased, serum 1,25- (OH) _2-D_3 decreased. X-ray shows subperiosteal absorption, epiphyseal spondylolisthesis, osteoporosis and rickets bones. Pathological examination showed osteomalacia and fibrous osteitis. The pathogenesis of nephropathic osteodystrophy is not yet fully understood