黄腐酸(Fulvic acid)可引起细胞的氧化性损伤,导致大鼠血液、肝脏、肌肉及软骨等组织中的 GSH-Px 活力降低和 SOD 活力升高.这些结果提示黄腐酸可能引起机体组织的氧化-抗氧化平衡失调.已知黄腐酸可促进体外黄嘌呤氧化酶-黄嘌呤体系产生超氧自由基(·o_2~-),它所含的醌式结构部分可能参与生物体中单电子氧化还原过程.但黄腐酸是否可以诱导细胞产生活性氧还未见报道.本文研究了大鼠肝细胞在黄腐酸作用下是否可产生释放活性氧自由基及可能 Fulvic acid can cause oxidative damage of cells, resulting in decreased GSH-Px activity and SOD activity in blood, liver, muscle and cartilage, etc. These results suggest that fulvic acid may cause body tissue Of the oxidation-oxidation balance imbalance is known fulvic acid can promote xanthine oxidase - xanthine system produce superoxide radical (· o_2 ~ -), which contains quinoid structure part may participate in the organism single However, whether fulvic acid can induce the production of reactive oxygen species in cells has not been reported.In this paper, whether the release of reactive oxygen species from the liver cells of rat hepatocytes under the action of fulvic acid