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半夏有治妊娠呕吐之功,妇科临床对选用其它止呕药效果不佳的病例,应用半夏常获良效。但有药书中记载半夏有毒,孕妇慎用。半夏的毒性实验已有报导,但未见有对遗传物质影响的报告。为检测半夏对母体及子代的遗传毒性作用,本实验以妊娠小鼠为材料,以姐妹染色单体交换(SCE)和染色体畸变(CA)为指标,胎鼠肝细胞与孕鼠骨髓细胞相比较,评价半夏的遗传毒性作用。材料与方法妊娠12～14天孕鼠25只,随机分五组:空白对照组每只每日早晚灌生理盐水(0.5ml/次);实验组姜半夏分三个剂量即30g/kg,
Pinellia has the power to treat pregnancy vomiting, gynecological clinical use of other anti-vomiting drugs ineffective cases, the application of Pinellia often get good results. However, there are medicinal records recorded Pinellia toxic, pregnant women with caution. Toxicity experiments of Pinellia ternate have been reported, but no reports of effects on genetic material have been reported. In order to detect the genotoxicity of Pinellia ternate and its offspring, we used pregnant mice as the materials, and used sister chromatid exchange (SCE) and chromosome aberration (CA) as indexes to measure fetal rat hepatocytes and pregnant mice’s bone marrow cells. In comparison, Pinellia genotoxicity was evaluated. Materials and Methods Twenty-five pregnant rats aged 12 to 14 days were randomized into five groups: the control group received saline (0.5 ml/day) daily morning and evening; the experimental group received three doses of 30 g/kg.