报道两例着色性干皮病患者的发病、癌变和治疗经过,分析讨论本病癌变的诱因和癌变的机理。认为除紫外线之外,放射线、机械损伤、热力刺激等亦可成为本病癌变的诱因。关于癌变后的治疗,建议废弃放疗,倡用争光霉素(局部或全身)、卡介苗(局部)等。提出应用遗传工程学方法矫正本病患者遗传缺陷的设想。 The incidence, canceration and treatment of two cases of xeroderma pigmentosum were reported and the causes of carcinogenesis and the mechanism of carcinogenesis were analyzed. It is considered that in addition to ultraviolet rays, radiation, mechanical damage, thermal stimuli, etc., can also be a cause of cancer of the disease. For post-cancerous treatment, it is recommended to dispose of radiotherapy, promote bleomycin (local or systemic), and BCG (partial). The idea of ​​applying genetic engineering methods to correct genetic defects in patients with this disease was proposed.