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神经组织是神经元树突和轴突通过突触连接形成的神经纤维网络,而树突和轴突之所以能准确到达其特定靶结构并与之建立结构和功能联系则取决于突起末端生长锥的运动。生长锥能依据周围环境的生长和导向信号而改变自身的形状,具有高度的能动性。其动力来源在于其本身微管和微丝丰富而准确的运动,无论是突起的生长,还是其损伤后的再生,生长锥内微管和微丝的不断聚合和解聚,二者相互作用并不断发生独特的空间和位置变化,从而改变生长锥的生长行为,以及神经元的形态和它们之间形成的网络结构。对生长锥细胞骨架工作模式的认识,有助于理解突起的生长和再生过程。
Nerve tissue is a network of neuronal fibers formed by dendrites and axons of neurons connected by synapses, and the ability of dendrites and axons to accurately reach and establish structural and functional relationships with their specific target structures depends on the growth tip exercise. The growth cone can change its shape according to the growth and orientation of the surrounding environment and has a high degree of motivation. Its motive force lies in the rich and accurate movement of its own microtubules and microfilaments, whether it is protuberant growth, or its regeneration after injury, the continuous polymerization and depolymerization of microtubules and microfilaments in the growth cone, and the two interact with each other continuously A unique spatial and positional change occurs that alters the growth behavior of the growth cone and the morphology of the neurons and the network structures that form between them. Understanding of the working cones of growth cone helps to understand the processes of protrusion and regeneration.