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目的:观察仙灵骨葆胶囊改善男性不育患者精液质量的情况。方法:女方生育功能正常的男性不育患者66例,口服仙灵骨葆胶囊2~4个月,观察治疗前后精液质量并进行精子形态学分析。结果:治疗2个月后,精子密度有所提高,但无统计学差异(P>0.05);精子存活率和活动率也无明显变化(P>0.05);治疗后正常形态精子百分率明显升高,其中正常形态精子百分率≥15%者,由治疗前的25.8%(17/66)增加为57.6%(38/66)(P<0.05),而正常形态精子百分率<9%者,由治疗前的53.0%(35/66)下降为25.8%(17/66);7例少精子症者用药前精子正常形态百分率平均为5.8%,服药4个月后平均为10.9%,与服药前有明显差异(P<0.05)。治疗期间有5例患者配偶怀孕。结论:仙灵骨葆胶囊对男性精液质量有改善作用,能明显提高正常形态精子百分率,少精子症者更明显。
Objective: To observe the improvement of semen quality in male infertility patients treated with Xianlingguyu Capsule. Methods: 66 female infertility patients with normal fertility were treated with Xianlingguyu capsule for 2 to 4 months. The semen quality before and after treatment was observed and sperm morphological analysis was performed. RESULTS: After 2 months of treatment, the sperm density increased but there was no statistical difference (P>0.05). There was no significant change in the sperm survival rate and activity rate (P>0.05). The percentage of normal spermatozoa after treatment increased significantly. Among them, the percentage of normal spermatozoa ≥15% increased from 25.8% (17/66) before treatment to 57.6% (38/66) (P<0.05), while the percentage of normal spermatozoa was less than 9% before treatment. The rate of 53.0% (35/66) decreased to 25.8% (17/66); the average percentage of normal sperm morphology in the 7 cases with oligospermia was 5.8%, and the mean rate was 10.9% after 4 months of medication. Difference (P<0.05). Five patients were pregnant during treatment. Conclusion: Xianlingguyu Capsule can improve the quality of semen in males, and can significantly increase the percentage of normal spermatozoa, and it is more obvious in those with less sperm.