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利用均值血药浓度确定药物动力学参数,并估计药物动力学参数的标准差的方法已经见报。本文将岭回归应用于药物动力学参数标准差的估计,表现出计算结果稳定、准确、可靠的优点。
Methods of using mean plasma concentrations to determine pharmacokinetic parameters and to estimate standard deviations of pharmacokinetic parameters have been reported. In this paper, ridge regression is applied to the estimation of standard deviation of pharmacokinetic parameters, showing the advantages of stable, accurate and reliable calculation.