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动物实验证明:接种肿瘤的小鼠免疫功能明显低下;手术可进一步增加免疫功能损伤;氟烷麻醉对免疫功能影响不大。临床资料证明:手术后第1天免疫功能下降最明显;术后2周基本回复到术前水平。本文讨论了癌瘤手术对免疫损伤的各种可能因素。提出如下建议:①术前即应开始免疫支持治疗。②术中应用氟烷麻醉,操作要细致,尽量减少出血和输血。③术后少用或不用激素,早期继续免疫支持治疗,术后化疗应在2周,免疫功能回复后进行。
Animal experiments proved that mice immunized with tumors have significantly lower immune function; surgery can further increase immune function damage; halothane anesthesia has little effect on immune function. Clinical data showed that the immune function decreased most significantly on the first day after the operation; it basically returned to the preoperative level after 2 weeks. This article discusses the various possible factors of immunological injury in cancer surgery. Make the following recommendations: 1 The immune support therapy should be started before surgery. 2 Intraoperative halothane anesthesia, careful operation, minimize bleeding and blood transfusion. 3 Use less or no hormone after the operation and continue the immune support treatment in the early stage. Postoperative chemotherapy should be performed within 2 weeks after the immune function is restored.