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目的:分析和探讨中草药及其制剂所致药物性肝损害的临床特点及其防治措施。方法:采用回顾性分析方法,选取2012年4月—2015年4月期间就诊的处方用中草药及其制剂所致药物性肝功能损害患者60例临床资料,分析患者所用中草药及其制剂致肝功能损害临床表现以及症状转归等特点。结果:临床分型中,最多见的是肝细胞型31例占51.67%;其次是胆汁淤积型17例占28.33%;再则是混合型12例占20.00%;肝损害发生时间在4 d~4周的用药期间,许多中草药及其制剂都能够导致药物性肝损害的发生,特别是用于皮肤病和风湿性关节病等治疗的中草药及其制剂,不同的给药途径均可发生。结论:用药4周内最容易出现药物性肝损害,中草药及其制剂所致药物性肝损害常为肝细胞型,在临床上采用中草药及其制剂治疗疾病时治疗过程中应检测患者肝功能等指标。
Objective: To analyze and discuss the clinical features and preventive measures of drug-induced liver damage caused by Chinese herbs and their preparations. Methods: A retrospective analysis method was used to select the clinical data of 60 patients with drug-induced liver dysfunction caused by prescriptions of Chinese herbal medicines and their preparations during the period from April 2012 to April 2015, and to analyze the liver function Damage to clinical manifestations and symptoms and other characteristics. Results: The most common clinical types were hepatocellular type in 31 cases (51.67%), followed by cholestatic type in 17 cases (28.33%), mixed type in 12 cases (20.00%) and liver damage in 4 days During the 4-week treatment period, many Chinese herbal medicines and their preparations can cause the development of drug-induced liver damage, especially for Chinese herbal medicines and their preparations for the treatment of dermatosis and rheumatoid arthritis. Various administration routes can occur. Conclusion: Drug-induced liver damage is most likely to occur within 4 weeks after treatment. The drug-induced liver damage caused by Chinese herbal medicine and its preparation are often hepatocellular type. In clinical practice, Chinese herbal medicine and its preparation should be used to detect liver function, etc. during treatment index.