扑热息痛(I)到目前为止仍是一种广泛应用于临床较安全的解热镇痛药,但存在着水溶性很小,剂型范围较窄等缺点。为了提高其生物利用度、提高其水溶性,作者合成了它的前体药物,以便于给药后在体内分解为原来的母体药物,可使疗效增强,扩大临床应用范围,是具有一定的现实意义的。 Paracetamol (I) is still a kind of antipyretic analgesic which is widely used in clinical practice so far. However, there are some shortcomings such as small water solubility and narrow dosage form. In order to improve its bioavailability and improve its water solubility, the authors synthesized their prodrugs so that they can be decomposed into the original parent drug after administration, which can enhance the therapeutic effect and expand the scope of clinical application, which is a certain reality meaningful.