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目的:对公开发表的有关中草药治疗糖尿病的有效性和安全性方面的研究资料进行系统考察。方法:共检索分析了中文和英文公开发表的108个涉及29种中草药(单味药或复方制剂)治疗人类糖尿病方面的研究资料,实验对象为临床确诊的糖尿患者或糖耐量受损的患者(不包括动物),主要观测的指标为血糖及高血糖症状(不包括糖尿病并发症:神经系统病变、糖尿病肾病、视网膜病变等),采用the Jadad scale评分标准对检索的临床随机对照实验进行评价筛选。结果:目前尚无充足的证据表明单个中草药制剂能够有效控制糖尿患者的血糖水平,但这些中草药制剂大多都是安全的。结论:设计严谨的临床随机对照实验结果表明,瓜籼稻和西洋参是很有潜力的抗糖尿病中草药,其次是匙羹藤、芦荟、苦瓜和仙人掌等。
OBJECTIVE: To systematically investigate the publicly available research data on the effectiveness and safety of herbal medicine in the treatment of diabetes mellitus. METHODS: A total of 108 Chinese and English publicly available published research data on 29 Chinese herbal medicines (single herbs or compound preparations) for the treatment of human diabetes mellitus were collected from clinically diagnosed diabetics or impaired glucose tolerance patients Excluding animals), the main indicators for observation were blood glucose and hyperglycemia (excluding diabetic complications: neurological diseases, diabetic nephropathy, retinopathy, etc.). The clinical randomized controlled trials were screened using the Jadad scale scale . Results: There is not enough evidence that a single Chinese herbal medicine can effectively control the blood sugar level of diabetic patients, but most of these herbal preparations are safe. CONCLUSIONS: Well-designed clinical randomized controlled trials have shown that indica rice and American ginseng are highly potential anti-diabetic herbs followed by Gymnema sylvestre, Aloe vera, Bitter melon and Opuntia.