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目的探究成都地区7220例不孕不育患者的染色体核型异常情况。方法对2015年7月至2016年6月在我院就诊的7220例不孕不育患者进行回顾性分析。采用外周血淋巴细胞培养并制备标本,应用G显带技术进行染色体核型分析。结果7220例不孕不育患者染色体异常110例,异常检出率为1.52%(110/7220)。其中染色体数目异常48例,均为性染色体数目异常,异常检出率为0.66%(48/7220)。染色体结构异常为62例,异常检出率为0.86%(62/7220),其中性染色体结构异常为4例,异常检出率为0.05%(4/7220);常染色体结构异常为58例,异常检出率为0.80%(58/7220)。染色体多态性222例,发生率为3.07%(222/7220)。结论染色体异常是导致不孕不育的常见因素之一,对不孕不育患者的染色体核型分析具有重要意义。
Objective To investigate the chromosomal abnormalities in 7220 inpatients in Chengdu area. Methods A retrospective analysis of 7220 inpatients with infertility treated in our hospital from July 2015 to June 2016 was conducted. Peripheral blood lymphocytes were used to culture and prepare specimens. K - banding technique was used to analyze the karyotypes. Results There were 110 cases of chromosome abnormalities in 7220 cases of infertility infertility. The detection rate was 1.52% (110/7220). The number of abnormal chromosomes in 48 cases, all of the sex chromosome abnormalities, the abnormal detection rate was 0.66% (48/7220). Chromosome structural abnormalities were 62 cases, the abnormal detection rate was 0.86% (62/7220), including 4 cases of sex chromosome abnormalities, abnormal detection rate was 0.05% (4/7220); autosomal abnormalities were 58 cases, The anomaly detection rate was 0.80% (58/7220). Chromosome polymorphism in 222 cases, the incidence was 3.07% (222/7220). Conclusion Chromosomal abnormalities are one of the common factors that lead to infertility, which is of great importance to the karyotype analysis of infertile patients.