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目的：对８例心脏瓣膜置换病人ｐｏ华法林５～１０ｍｇ后的对映体药动学过程进行评价。方法：采用正相ＨＰＬＣ拆分和测定病人首次ｐｏ华法林后２４ｈ内血浆中对映体，以非线性最小二乘法估算药动学参数。结果：华法林对映体浓度普遍低于国外同等剂量下的浓度。Ｓ华法林的α和Ｃｌ明显大于Ｒ华法林（Ｐ＜０．０１），Ｓ华法林的ｔ１／２（β）明显小于Ｒ华法林（Ｓ：１７．１７ｈ；Ｒ：２４．１９ｈ；Ｐ＜０．０１），而两个对映体的Ｖｄ无显著差异（Ｐ＞０．０５）。结论：研究表明中国人对华法林对映体的体内过程有明显的立体选择性和特性，为今后合理用药打下了基础。
OBJECTIVE: To evaluate the enantiomeric pharmacokinetics of 8 warfarin-treated patients with warfarin 5 ~ 10 mg. Methods: The enantiomers of plasma were separated and determined by normal phase HPLC in 24h after the first po warfarin treatment. The pharmacokinetic parameters were estimated by the non-linear least square method. Results: The warfarin enantiomer concentrations were generally lower than those of the foreign counterparts. Α and Cl of S-warfarin were significantly higher than those of R-warfarin (P <0.01), and t1-2 (β) of S-warfarin was significantly lower than that of R-warfarin R: 24.19h; P <0.01). There was no significant difference in Vd between the two enantiomers (P> 0.05). Conclusion: The study shows that Chinese people have obvious stereoselectivity and characteristics on the process of warfarin enantiomer in vivo, which lays the foundation for rational drug use in the future.