近十余年来,一向棘手的尤文氏肉瘤的治疗有了显著进展,尤以化疗更引人注目。自1921年Ewing描述本病以来,认识不断深入。起初,从组织学角度,有人认为该瘤来源于骨髓内血管内皮细胞,曾名为“弥漫性内皮瘤”或“内皮性骨髓瘤”。瘤细胞呈均匀一致的小圆细胞,故又称“圆细胞肉瘤”。现据电镜观察,瘤细胞为未分化网状细胞,故又称“未分化网状细胞肉瘤”。生物化学方面的研究证明,该瘤与极易相混淆的骨原 Over the past decade or so, there has been remarkable progress in the treatment of the intractable Ewing’s sarcoma, especially with chemotherapy. Since Ewing described the disease in 1921, his understanding has continued. Initially, from the perspective of histology, some people believe that the tumor originated from vascular endothelial cells in the bone marrow. It was once called “diffuse endothelium” or “endothelial myeloma.” The tumor cells are uniformly small round cells, it is also called “round cell sarcoma.” According to electron microscopic observations, the tumor cells are undifferentiated reticular cells, so it is also called “undifferentiated reticular cell sarcoma.” Biochemical research proves that the tumor is very easy to be confused with the original bone