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作者随访了经乙型肝炎疫苗免疫的773名男性同性恋者5年来抗-HBs消长情况,同时观察了对乙型肝炎疫苗无应答及低水平应答者的再接种效果。结果表明,635人(82%)最大抗-HBs水平>9.9样本比率单位(SRU);69人抗-HBs水平≤9.9SRU;69人无抗体应答。5年随访期间,最大抗-HBs>9.9SRU者,抗-HBs水平下降缓慢。5年后,15%测不到抗-HBs,27%抗-HBs在10SRU以下,抗-HBs水平>100SRU者仅占14%。抗-HBs的持久性与接种疫苗后抗-HBs的最高水平直接相关:
The authors followed 773 homosexuals immunized with Hepatitis B vaccine for 5 years to report the decline of anti-HBs, and also observed the effect of re-vaccination against Hepatitis B vaccine nonresponders and low-level responders. The results showed that 635 (82%) had the highest anti-HBs level> 9.9 sample ratio units (SRU); 69 had anti-HBs level <9.9 SRU; and 69 had no antibody response. During the 5-year follow-up, those with the largest anti-HBs> 9.9SRU showed a slow decline in anti-HBs levels. After 5 years, 15% did not detect anti-HBs, 27% anti-HBs was below 10 SRU and only 14% anti-HBs> 100 SRU. The persistence of anti-HBs is directly related to the highest level of anti-HBs after vaccination: