论文部分内容阅读
目的研究多发创伤病人早期血清性激素睾酮、雌二醇变化与创伤严重度评分及格拉斯哥昏迷评分的关系,探讨创伤后两者及两者比值变化的意义。方法急诊就诊的男性多发创伤患者95例,就诊时间均在伤后24h内,即时采集血样,采用放射免疫双抗体沉淀法测定病人早期血清中睾酮、雌二醇含量。按照ISS评分予以分组,其中合并颅脑损伤病人按GCS评分分组。并与15例正常对照组比较,同时各分组间比较睾酮、雌二醇含量以及雌二醇/睾酮变化。结果多发创伤病人早期,创伤越重,睾酮值降低越明显,雌二醇值升高。严重创伤组(ISS>25分)睾酮、雌二醇、雌二醇/睾酮值与其他组间对比有显著差异(P<0.01)。合并颅脑损伤组按GCS评分分组:5≥GCS≥3组、8≥GCS>5组与对照组比较有显著性差异(P<0.01)。结论血清性激素睾酮、雌二醇水平的改变以及雌二醇/睾酮的改变与严重创伤、颅脑损伤的严重程度相关。可作为判断伤情、观察预后的参考指标。
Objective To study the relationship between the changes of serum sex hormones testosterone and estradiol, the severity of trauma and the Glasgow coma score in patients with multiple traumatic injuries and to explore the significance of the changes of both trauma and ratio. Methods A total of 95 male patients with multiple traumas were enrolled in this study. All the patients were treated within 24 hours after injury. Blood samples were taken immediately and the contents of testosterone and estradiol in the early serum of the patients were determined by radioimmunoassay. According to ISS score to be grouped, including patients with brain injury by GCS score grouping. And compared with 15 normal control group, while the testosterone and estradiol levels and the changes of estradiol / testosterone in each group were compared. Results In the early stage of multiple trauma patients, the heavier the trauma, the more obvious the decrease of testosterone value and the increase of estradiol value. There was significant difference between testosterone, estradiol and estradiol / testosterone levels in severe trauma group (ISS> 25) (P <0.01). The patients with brain injury group were grouped according to the GCS score: 5≥GCS≥3 group, 8≥GCS> 5 group, there was significant difference compared with the control group (P <0.01). Conclusion The changes of serum sex hormone testosterone, estradiol levels and the changes of estradiol / testosterone are related to the severity of trauma and head injury. Can be used as a judgment of injury, the prognostic reference index.