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目的:探讨纤维蛋白原、白细胞和中性粒细胞等炎症因子对冠心病(CHD)发病的影响。方法:1487例住院患者根据经冠脉造影结果分为CHD组(1017例)和非CHD对照组(470例)。详细记录病史,体检资料,检验血常规,血脂,血糖,血浆纤维蛋白原等含量,并对结果进行比较分析。结果:与非CHD对照组比较,CHD组年龄[(58.01±11.15)岁比(60.18±11.85)岁],吸烟(34.5%比57.7%)、高血压(43.2%比66.6%)、糖尿病(11.5%比30.5%)所占比例,甘油三酯[(1.65±0.80)mmol/dl比(1.79±1.28)mmol/dl]、纤维蛋白原[(311.51±86.84)mg/dl比(362.38±94.73)mg/dl]水平和外周血白细胞计数[(6.43±4.76)109/L比(7.18±2.64)109/L]均明显增加(P<0.05),高密度脂蛋白胆固醇水平明显降低[(1.18±0.32)mmol/dl比(1.11±0.30)mmol/dl,P<0.001];中性粒细胞计数、总胆固醇和低密度脂蛋白胆固醇水平在CHD组也呈增高趋势,但两组间无显著性差异(P>0.05)。Logistic回归分析显示年龄、吸烟、高血压、糖尿病、纤维蛋白原和外周血白细胞计数对CHD均有显著影响(r=1.00～2.81,P<0.05)。结论:除吸烟、糖尿病、高血压、脂质代谢紊乱外,炎症因子纤维蛋白原、外周血白细胞水平升高也是冠心病危险因素。
Objective: To investigate the effect of inflammatory factors such as fibrinogen, leukocyte and neutrophil on the incidence of coronary heart disease (CHD). Methods: 1487 hospitalized patients were divided into CHD group (1017 cases) and non-CHD control group (470 cases) according to coronary angiography results. Detailed records of medical history, physical examination, blood tests, blood lipids, blood glucose, plasma fibrinogen and other content, and the results were compared. Results: Compared with non-CHD control group, the CHD group had significantly higher age (58.01 ± 11.15 years vs 60.18 ± 11.85 years), smoking (34.5% vs 57.7%), hypertension (43.2% vs 66.6%) and diabetes %, And the proportion of fibrinogen [(311.51 ± 86.84) mg / dl (362.38 ± 94.73)%] mg / dl] and peripheral blood leukocyte count ([(6.43 ± 4.76) 109 / L vs (7.18 ± 2.64) 109 / L] 0.32) mmol / dl (1.11 ± 0.30) mmol / dl, P <0.001]; neutrophil count, total cholesterol and low density lipoprotein cholesterol levels also increased in CHD group, but there was no significant difference between the two groups Difference (P> 0.05). Logistic regression analysis showed that age, smoking, hypertension, diabetes mellitus, fibrinogen and peripheral blood leukocyte count had significant effects on CHD (r = 1.00-2.81, P <0.05). Conclusion: In addition to smoking, diabetes, hypertension, lipid metabolism disorders, inflammatory cytokines fibrinogen, peripheral leukocyte levels are also risk factors for coronary heart disease.