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目的:分析甲状腺功能亢进(甲亢)对于心室复极化的影响。方法:计算机检索PubMed、EMBASE、中国期刊全文数据库、维普数据库、万方数据库于1960年～2013年12月公开发表的相关文献,用Revman 5.2进行meta分析。结果:分析纳入7项病例对照研究,甲亢病例425例,对照组366例。甲亢时心率校正的QT间期(QTc)较对照组显著延长(MD=18.46,95%CI:10.19-26.73,P<0.01),心率校正的QT离散度(QTcd)也显著延长(MD=19.38,95%CI:13.59-25.18,P<0.01)。QT间期与对数化后的促甲状腺素(TSH)呈负相关(Pearson相关系数r=-0.748,P<0.01;加权线性回归系数R2=0.557,P<0.01)。结论:甲亢患者的心室复极化显著延长。
Objective: To analyze the effect of hyperthyroidism (Hyperthyroidism) on ventricular repolarization. Methods: PubMed, EMBASE, Chinese Journal Full-text Database, VIP database, Wanfang database published in 1960 ~ December 2013 published the relevant literature, with Revman 5.2 for meta-analysis. RESULTS: Seven case-control studies were included in the analysis, 425 cases of hyperthyroidism and 366 cases of control. The QT interval (QTc) of heart rate corrected for hyperthyroidism was significantly longer than that of the control group (MD = 18.46,95% CI 10.19-26.73, P <0.01), and the QTcd corrected for heart rate was also significantly prolonged (MD 19.38 , 95% CI: 13.59-25.18, P <0.01). QT interval was negatively correlated with logarithmic TSH (Pearson correlation coefficient r = -0.748, P <0.01; weighted linear regression coefficient R2 = 0.557, P <0.01). Conclusion: Ventricular repolarization in patients with hyperthyroidism was significantly prolonged.