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作者报告1例银屑病患者经补骨脂素加长波紫外线照射(PUVA)治疗后在皮肤上引起的不寻常的组织病理改变。患者女性,39岁,皮肤浅色,曾以PUVA治疗,其最小红斑量是1焦耳/平方厘米,在7个月的治疗中共接受175焦耳的照射量。在大腿原银屑病皮损消退处遗有光毒性烧伤后的发亮的色素减退斑。在该处取活检以多种染色法检查结果如下。组织病理改变,表现于表皮内,表皮与真皮交界处及真皮上层。在表皮内基底细胞的大小及形状不一致,但未发现有色素细胞。在明显肿大充满糖原的棘细胞之间,稀疏地分布有角化不良细胞。棘细胞中有些细胞核是不典型的,有一个至几个明显的核仁。颗粒层呈局灶性变薄。在分层及致密的正
The authors report an unusual histopathologic change on the skin following treatment with psoralen plus long-wave ultraviolet (PUVA) in 1 patient with psoriasis. The patient, female, 39 years old, had a light skin color and had been treated with PUVA. The minimum erythema dose was 1 Joule/cm2 and a total of 175 Joules of irradiation was received during the 7 months of treatment. In the area where the thigh original psoriasis lesions disappeared, there was a shiny pigmentation spot after phototoxic burns. Biopsies were taken at this site and the results of the various staining tests were as follows. Histopathological changes are manifested in the epidermis, at the junction of the epidermis and the dermis, and in the upper dermis. The size and shape of the basal cells in the epidermis were inconsistent, but no pigment cells were found. Between the enlarged swollen glycogen-rich prickle cells, poorly distributed keratinocytes are sparsely distributed. Some of the nucleus in the spine cells are atypical, with one to several distinct nucleoli. The particle layer is focally thin. Layered and dense positive